How To Choose The Best Cleanse & Detox Supplement in 2021

Latest update: August 25, 2021

Advertiser Disclosure

Top Reviews

Unique Features


Costs & More

Top Cleanse & Detox Supplements 2021

1. Primal Total Cleanse

by Primal Harvest [1]


1533 votes


Ingredient Quality Control

Potency & Estimated Efficacy

Price / Customer Value

Return Policy

Overall Customer Happiness








90-Day Money-Back Guarantee 

Top-Rated Customer Support 

Easy-To-Swallow Capsules

Gentle, Natural, & Effective Blend

Certified Safety & Purity Testing 

Made in the USA 

Only Available Online

Sometimes Runs Out of Stock

The Bottom Line

Primal Total Cleanse by Primal Harvest features a gentle yet effective blend of the top detoxifying ingredients to help eliminate waste and flush toxins from your body. Expertly formulated for natural and safe cleansing, it contains premium ingredients like acai berry fruit, fennel seeds, aloe vera leaf, senna leaf, cascara sagrada, and Lactobacillus acidophilus.

This premium cleanse formula provides a comprehensive approach to supporting energy, digestion, and healthy detoxification from a holistic wellness perspective, with 
no unnecessary fillers, synthetic additives, hidden ingredients or harsh laxatives. It was also one of very few products to include independent third-party lab testing, and abide by strict NSF and GMP manufacturing practices here in the USA.

This cleanse & detox supplement features superior value and quality at a
reasonable price point. Their top-notch customer service scores and generous 90-day money-back guarantee is indicative of a brand that stands behind their customers and the quality of their products. When compared to other top competitors, Primal Total Cleanse by Primal Harvest was unrivaled in effectiveness, quality, safety, value, and customer service. 

Click to Shop Now
Make a Smarter Choice

2. 15 Day Cleanse

by Youth & Tonic

B+ Rating



Contains Quality Natural Ingredients

Formulated in The USA

GMP certified

15-Day Detox is a bold claim

Some users report feeling very little difference after 1 bottle

Click to Shop Now

372 votes


Ingredient Quality Control

Potency & Estimated Efficacy

Price / Customer Value

Return Policy

Overall Customer Happiness






15 Day Cleanse by Youth & Tonic features 30 veggie capsules containing quality natural ingredients. This product was formulated in the USA and aims at providing constipation relief and regular bowl movement support for those who experience mild problems, and need gentle relief. The other ingredients aim to clean the colon, and it is recommended to increase water intake when starting this product. 

3. Liver 21 Day Cleanse

by Dr. Tobias

C+ Rating



Formulated to clean and repair the liver

Manufactured in the USA and made from non-GMO, plant-bassed ingredients.

Contains gluten which can upset leaky gut

Some users reported feeling ill, and even some minor swelling after taking this product. 

Click to Shop Now

567 votes


Ingredient Quality Control

Potency & Estimated Efficacy

Price / Customer Value

Return Policy

Overall Customer Happiness






Liver 21 Day Cleanse by Dr. Tobias was formulated to help cleanse and repair the liver but contains gluten and wheat, which can cause some upset stomachs and even worsen leaky gut in some situations. This product is manufactured in the USA from non-GMO, plant-based ingredients, and is third-party tested for purity, effectiveness, and safety. 

4. Detox

by Cannabiology

C Rating




Easy to swallow soft capsules

There is no product that can detox the body in 5 Days

Click to Shop Now

937 votes


Ingredient Quality Control

Potency & Estimated Efficacy

Price / Customer Value

Return Policy

Overall Customer Happiness






Questionable efficacy in comparison to other brands

Detox by Cannabiology is a great option for vegans and those who need soft capsules. But, some of the claims are too strong to be taken seriously. On a positive note, the company is great at addressing customer's concerns, and cranberry extract can have positive effects for cleaning out toxins in the body and preventing UTIs. 

5. Natural Colon Cleanser

by The Enclare

C Rating



Contains probiotics and powerful herbs

Made in the USA, non-GMO, and keto friendly 

Products claims to be vegetarians but contains gelatin

Click to Shop Now

248 votes


Ingredient Quality Control

Potency & Estimated Efficacy

Price / Customer Value

Return Policy

Overall Customer Happiness






Many users experienced diarrhea

Natural Colon Cleanser 15 Day Detox by The Enclare made the final spot on our list because it is offers a complete formula, but many users experienced negative effects while taking this product. Diarrhea, abdominal pain, cramping, etc.  Another issue with this product is that it claims to be suitable for vegetarians but the capsules are made from bovine gelatine, so make sure to read the label if you follow a specialty diet. 

Best Overall

Read Review

by Primal Harvest [1]

1834 Reviews

Primal Total Cleanse

US-Made with Premium Ingredients

Contains Herbs and Probiotics

Easy to Swallow Capsules

Made in a GMP-Certified Facility

Free Shipping on Orders over $75

2,367 people chose this today

*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided by this website or this company is not a substitute for a face-to-face consultation with your physician and should not be construed as individual medical advice. The testimonials on this website are individual cases and do not guarantee that you will get the same results. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only.

© 2021 
All Rights Reserved. 

Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Smarter Choices has with our top picks.

[1] we have a financial relationship with some of our top picks and partners

What are Cleanse and Detox Supplements?

There’s no doubt that body cleansing supplements have become hugely popular in 2020. The goal of these dietary supplements is to naturally give your system a helping hand, by optimizing its natural detoxification system.

This can help restore optimal health and physical balance without the use of potentially harmful drugs or controversial colon cleansing techniques.

These supplements can be found in capsule form, as well as some teas, smoothies, and water-based products aimed at flushing out toxins with naturally-based ingredients. 

Cleanse & Detox Supplement Must-Haves:

*Individual results may vary

Fennel Seed: Fennel seeds, rich in both antioxidants and fiber, have been shown to help relax your digestive muscles and aid in the elimination of toxins from your body. When taken as part of a healthy routine, fennel seeds may help decrease water retention and bloating, support a healthy metabolic rate, normalize appetite, and prevent gas.

Aloe Vera Leaf: Extremely hydrating and rich in phytonutrients, aloe vera has been historically used for centuries for its natural cleansing and antioxidant properties. Although more clinical research is still needed, aloe vera shows promising potential for supporting digestion, detoxification, liver health, and providing relief from constipation and skin irritation

Lactobacillus Acidophilus: Laboratory research has found that certain probiotics, especially Lactobacillus acidophilus, have properties that can bind to toxins and harmful pollutants in your body and aid in healthy detoxification. These probiotics are also essential to good overall health and can aid in boosting immunity, nutrient absorption, and digestive health.

Senna LeafOriginally from Egypt, many studies have found that senna leaf can aid digestion and may even relieve occasional constipation, gas, and bloating. Acting as a gentle herbal laxative, it can help support a healthy body composition and metabolism when used in combination with exercise, good nutrition, and plenty of rest.

Cascara SagradaCascara sagrada is a cleansing herb and gentle laxative that has been traditionally used to help safely flush out toxins by emptying bowels and promoting more regular bowel movements. Besides aiding with constipation and bloating, it has also been shown to have a positive effect on skin clarity and hydration. 

Our Research-Backed 10-Point System

1. Price and Value for Money
2. Label Accuracy
3. Product Safety
4. Third Party Verifications
5. Customer Reviews
6. Guarantee & Return Policy
7. Product Quality & Benefits
8. Ingredient Purity & Sourcing
9. Possibility of Results
10. Science, Research, and Development

The Results: How We Picked Our Top Choice

We’ve carefully reviewed the cleanse & detox supplements available on the market today, examining customer reviews, conducting in-depth research, and surveying numerous consumers of top brands. Here are our top picks:

  1. Pizzorno, Joseph. “Toxins From the Gut.” Integrative medicine (Encinitas, Calif.) vol. 13,6 (2014): 8-11.

  2. Roundtable on Environmental Health Sciences, Research, and Medicine; Board on Population Health and Public Health Practice; Institute of Medicine. Identifying and Reducing Environmental Health Risks of Chemicals in Our Society: Workshop Summary. Washington (DC): National Academies Press (US); 2014 Oct 2. 3, Current Regulatory Approaches to Dealing with Industrial Chemicals.

  3. Pizzorno, Joseph. “Is the Diabetes Epidemic Primarily Due to Toxins?.” Integrative medicine (Encinitas, Calif.) vol. 15,4 (2016): 8-17.

  4. Sutton, Patrice et al. “Toxic environmental chemicals: the role of reproductive health professionals in preventing harmful exposures.” American journal of obstetrics and gynecology vol. 207,3 (2012): 164-73. doi:10.1016/j.ajog.2012.01.034

  5. Pizzorno, Joseph. “Toxin Exposure Reduction.” Integrative medicine (Encinitas, Calif.) vol. 16,6 (2017): 8-10.

  6. Henkel, James S et al. “Toxins from bacteria.” EXS vol. 100 (2010): 1-29. doi:10.1007/978-3-7643-8338-1_1

  7. Fasano, A. “Toxins and the gut: role in human disease.” Gut vol. 50 Suppl 3,Suppl 3 (2002): III9-14. doi:10.1136/gut.50.suppl_3.iii9

  8. Barrett, Julia R. “The ugly side of beauty products.” Environmental health perspectives vol. 113,1 (2005): A24. doi:10.1289/ehp.113-a24

  9. Piazza, Mauri José, and Almir Antônio Urbanetz. “Environmental toxins and the impact of other endocrine disrupting chemicals in women's reproductive health.” JBRA assisted reproduction vol. 23,2 154-164. 30 Apr. 2019, doi:10.5935/1518-0557.20190016

  10. Cohen M. Environmental toxins and health--the health impact of pesticides. Aust Fam Physician. 2007 Dec;36(12):1002-4. PMID: 18075622.

  11. Crinnion WJ. Environmental medicine, part one: the human burden of environmental toxins and their common health effects. Altern Med Rev. 2000 Feb;5(1):52-63. PMID: 10696119.

  12. Pizzorno, Joseph. “Conventional Laboratory Tests to Assess Toxin Burden.” Integrative medicine (Encinitas, Calif.) vol. 14,5 (2015): 8-16.

  13. Phillips DH, Arlt VM. Genotoxicity: damage to DNA and its consequences. EXS. 2009;99:87-110. doi: 10.1007/978-3-7643-8336-7_4. PMID: 19157059.

  14. Genuis, Stephen J et al. “Clinical detoxification: elimination of persistent toxicants from the human body.” TheScientificWorldJournal vol. 2013 238347. 6 Jun. 2013, doi:10.1155/2013/238347

  15. National Research Council (US) Committee on National Monitoring of Human Tissues. Monitoring Human Tissues for Toxic Substances. Washington (DC): National Academies Press (US); 1991. 3, Toxicologic Issues.

  16. Allen, Jason et al. “Detoxification in naturopathic medicine: a survey.” Journal of alternative and complementary medicine (New York, N.Y.) vol. 17,12 (2011): 1175-80. doi:10.1089/acm.2010.0572

  17. Badgujar, Shamkant B et al. “Foeniculum vulgare Mill: a review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology.” BioMed research international vol. 2014 (2014): 842674. doi:10.1155/2014/842674

  18. Singh B, Kale RK. Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system. Food Chem Toxicol. 2008 Dec;46(12):3842-50. doi: 10.1016/j.fct.2008.10.008. Epub 2008 Oct 14. PMID: 18976688.

  19. Lee HS, Kang P, Kim KY, Seol GH. Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation. Korean J Physiol Pharmacol. 2015 Mar;19(2):183-9. doi: 10.4196/kjpp.2015.19.2.183. Epub 2015 Feb 25. PMID: 25729281; PMCID: PMC4342739.

  20. Khedmat, Hossein et al. “Aloe vera in treatment of refractory irritable bowel syndrome: Trial on Iranian patients.” Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 18,8 (2013): 732.

  21. Surjushe, Amar et al. “Aloe vera: a short review.” Indian journal of dermatology vol. 53,4 (2008): 163-6. doi:10.4103/0019-5154.44785

  22. Ibrahim F, Halttunen T, Tahvonen R, Salminen S. Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms. Can J Microbiol. 2006 Sep;52(9):877-85. doi: 10.1139/w06-043. PMID: 17110980.

  23. Zoghi A, Khosravi-Darani K, Sohrabvandi S. Surface binding of toxins and heavy metals by probiotics. Mini Rev Med Chem. 2014 Jan;14(1):84-98. doi: 10.2174/1389557513666131211105554. PMID: 24329992.

  24. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Senna. [Updated 2020 Apr 1].

  25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Cascara. [Updated 2017 Jan 23].

  26. Center for Food Safety and Applied Nutrition 2003. U.S. Food & Drug Administration.

  27. Madden GR, Schmitz KH, Fullerton K. A case of infantile star anise toxicity. Pediatr Emerg Care. 2012 Mar;28(3):284-5. doi: 10.1097/PEC.0b013e3182495ba7. PMID: 22391927.


Top Cleansing Ingredients in Detox Supplements

Here are the top naturally detoxifying ingredients that meet today’s top criteria for safety, effectiveness, and value:

What To Avoid In Your Cleanse & Detox Supplement

Unclear Labels: A quality cleanse supplement should clearly list exactly what’s included in the formula or proprietary blend. Avoid products lacking transparency that don’t list all of the specific ingredients included in the formula’s detoxifying blend.

Missing Safety Testing & Certifications: Choose a cleanse product that has been independently third party lab tested and manufactured in a GMP/NSP facility. Since supplements are not regulated by the FDA in the United States, these precautions will guarantee that the product is top quality and free from unwanted extras, such as contaminants, traces of heavy metals, or pesticides.

False or Misleading Claims: Beware of any cleanse supplements that claim their product treats or cures any specific disease or ailment, or promises miraculous, unrealistic, or misleading results (such as rapid weight loss). Always speak to your doctor before starting a new supplement routine, especially if you have a pre-existing condition or are taking prescription medications.

Suspiciously Cheap Products: When it comes to flushing out toxins, this is definitely not an area to test out suspiciously cheap products. There are plentiful options to choose from that are high value and still affordable. In this case, you do get what you pay for and it’s best to avoid low quality products that may contain harsh laxatives.

Japanese Star Anise: Sometimes confused with Chinese star anise, which looks nearly identical in its dried form, Japanese star anise contains sikimitoxin, a toxic ingredient that should never be consumed. The USDA issued a warning against teas containing star anise after this ingredient was associated with illness in approximately 40 individuals, including 15 infants.

Can cleanse supplements really help rid your body of excess toxins and waste?

Today, we are bombarded with more toxins than ever before. Whether it’s toxin-laden foods, cosmetics, pollution, or an endless list of chemicals, toxins have become an accepted part of our modern world.

 It’s estimated that there are at least 80,000 toxins surrounding us in our environment each day.

Although we may not be able to entirely avoid toxins in our daily lives, research has shown that, when combined with a healthy lifestyle, certain herbal extracts can naturally give the body a helping hand.

This is the reason why cleanse and detox products are becoming increasingly popular as people seek ways to combat toxin build-up and feel healthier, lighter, and more balanced. A holistic cleanse supplement can help give your system a much needed reset and restore wellness by effectively pushing excess toxins and waste from your body. 

What’s Wrong With Most Cleanse Supplements on the Market?

Just like the sophisticated systems your body uses to rid itself of toxins, detox and cleansing supplements can get pretty complex. There are endless products to choose from, varying formulas, countless red flags to look out for, and the challenge of matching gentle ingredients that safely compliment one another. 

All cleanse and detox supplements are NOT created equal.

Unfortunately, many generic cleansing supplements are packed with synthetic fillers, artificial colouring, harsh laxatives, or a long list of chemical ingredients most people can’t even pronounce.

Choosing the best possible detox support formula all comes down to knowing what to look for and what to avoid, so that you never waste your money or ineffective, low value, or potentially harmful products. The goal is to cleanse in a gentle, safe, and non-explosive manner.

Here are the top things to avoid when shopping for a cleanse and detox supplement:

What Type of Cleanse Supplement is Best?

Spotting the ultimate detox support supplement doesn’t need to be complicated. There are a few key must-haves you need to look for when choosing the right product for you.

Fortunately, we’ve done the homework for you. Based on expert advice, clinical studies, in-depth research, and honest feedback from informed shoppers, here are our top choices.

What Are Toxins?

The fact that toxins are all around us has caused the term to become loosely defined and widely used in many different ways. Toxins, in the general sense, are waste products that your body cannot fully eliminate through digestion or other means.

Toxins are usually categorized into three main sources: 

1) Environmental 
2) Bacteria from the digestive tract 
3) Cellular waste products

 Types of Toxins

Cellular waste products: Also known as metabolic waste, non-degraded substrates, and “cellular garbage disposal,” this term refers to leftover organic waste created by natural internal processes that slowly accumulates within aging cells over time.

Environmental: These are external substances, such as traces of heavy metals, phthalates, air pollutants, pesticides, and BPA. Many of these can be found in the air, household products, and cosmetics.

Digestive tract bacterial processing: Bacterial toxins can form in your digestive tract and lead to a number of gastrointestinal symptoms, such as infections in the GI tract. 

Anything that we eat, inhale, or place on our skin eventually makes its way into our bloodstream, where it then needs to be processed by our bodies. 

 Toxins May Damage The Body By...

Disrupting healthy hormone function and balance 
Harming important enzymes so that they can no longer function properly 
Displacing minerals like calcium that are needed to prevent bone loss 
Speeding up the aging process by potentially damaging DNA 
Weakening the body’s ability to detoxify, possibly the most dangerous issue 
And more...

The liver, colon, and kidneys are the three most essential organs when it comes to filtering and eliminating harmful substances, waste, and other toxins from the body.

Most of the time, a healthy body is able to neutralize toxins coming in and maintain normal homeostasis, but this isn’t always the case. 

Symptoms of Toxin Overload

Gas and bloating 

Fatigue and lethargy 

Constipation or diarrhea 

Dull, lackluster skin 

Excessive coating on the back of the tongue 

Bad breath 

Poor circulation 


Bad-smelling sweat

 Benefits of a Full Body Cleanse

Improved immunity 

Clearer skin 

Increased energy levels 

Fresher breath 

Enhanced weight loss efforts 

Greater mental clarity

Improved digestion and regularity 

*Individual results may vary 

Here’s how to spot the ultimate cleanse & detox formula for optimized digestion, metabolism, and energy.